منابع مشابه
White matter microstructure deteriorates across cognitive stages in Parkinson disease.
OBJECTIVES To characterize different stages of Parkinson disease (PD)-related cognitive decline using diffusion tensor imaging (DTI) and investigate potential relationships between cognition and microstructural integrity of primary white matter tracts. METHODS Movement Disorder Society criteria were used to classify 109 patients with PD as having normal cognition (PD-N, n = 63), mild cognitiv...
متن کاملImaging of white matter lesions.
Magnetic resonance imaging (MRI) is very sensitive for the detection of white matter lesions (WML), which occur even in normal ageing. Intrinsic WML should be separated from physiological changes in the ageing brain, such as periventricular caps and bands, and from dilated Virchow-Robin spaces. Genuine WML are best seen with T2-weighted sequences such as long TR dual-echo spin-echo or FLAIR (fl...
متن کاملCystlike white matter lesions in tuberous sclerosis.
PURPOSE To investigate the presence of small cystlike structures in the cerebral hemispheric white matter on MR images of patients with tuberous sclerosis. METHODS The MR images of 18 consecutive patients with tuberous sclerosis were reviewed retrospectively. RESULTS Eight of the 18 patients were found to have cystlike structures in the cerebral white matter. The signal intensity of these l...
متن کاملRegional volume analysis of the Parkinson disease brain in early disease stage: gray matter, white matter, striatum, and thalamus.
BACKGROUND AND PURPOSE Loss of dopaminergic neurons in the nigrostriatal pathway is well-documented in PD, whereas neuronal changes beyond the nigrostriatal pathway are uncertain. The purpose of our study was to estimate volume changes in the striatum and thalamus, which are areas of the basal ganglia, as well as in GM and WM located beyond the nigrostriatal pathway, in early-stage PD. MATERI...
متن کاملOrthostatic and Supine Blood Pressures Are Associated with White Matter Hyperintensities in Parkinson Disease
BACKGROUND AND PURPOSE Several reports on the elderly population have suggested that orthostatic hypotension is associated with white matter hyperintensities (WMH); however, little information is available on patients with Parkinson's disease (PD). METHODS We analyzed the association blood pressure profiles during tilt table testing with WMH scores in 117 patients with PD. WMH were rated usin...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2011
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2011.21